Capped at both termini
N-acetyl + C-amide resist peptidase cleavage.
FOR RESEARCH PURPOSES ONLY — This compound is not FDA approved. All data presented is from peer-reviewed literature for educational reference.
Neuropeptide
N-Acetyl Semax (Amidated)
- NA-Semax
- Semax amidate
- N-Ac-Met-Glu-His-Phe-Pro-Gly-Pro-NH₂
CAS: 80714-61-0
Acetylated + C-terminally amidated analog of Semax engineered to resist enzymatic degradation, used in research on BDNF/NGF expression, cholinergic neurotransmission, and cognitive function with extended half-life vs the parent peptide.
CoA available on request
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Improved proteolytic stability
Characterized in biological media vs parent Semax.
99%+ identity purity
HPLC + MS verified per batch. CoA included.
What Is N-Acetyl Semax (Amidated)?
N-Acetyl Semax is a synthetic derivative of Semax (Met-Glu-His-Phe-Pro-Gly-Pro, itself an ACTH(4-10) analog) in which the N-terminal methionine is acetylated and the C-terminal proline converted to a primary amide. Like other acetyl-amide modifications, the changes block aminopeptidase and carboxypeptidase cleavage, extending half-life relative to the parent. Pharmacodynamic signaling — BDNF and NGF up-regulation, neuroprotection in models of cerebral hypoxia, cholinergic and serotonergic effects — is preserved.
Technical specifications
Type
Synthetic acetylated heptapeptide amide
Formula
C₃₉H₅₄N₁₀O₁₀S (estimated)
Molecular weight
854.97 g/mol (estimated)
CAS number
80714-61-0
Appearance
White lyophilized powder
Identity purity
≥ 99% (HPLC + MS)
Peer-reviewed research
- Bioorg KhimStability of Semax acetyl to proteolysis in various biological media
- Bull Exp Biol MedKinetics of Semax penetration into the brain and blood of rats after its intranasal administration
Frequently researched together
IMPORTANT RESEARCH NOTICE
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.