IGF-I analogue
R3 substitution and 13-residue N-terminal extension.
CAS: 143045-27-6
An engineered analogue of insulin-like growth factor 1 with reduced binding-protein affinity, used in experimental studies of IGF signaling and growth-factor biology.

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R3 substitution and 13-residue N-terminal extension.
Model-dependent IGF and IGFBP interactions.
Review available batch-specific analytical records.
IGF-1 LR3, also called Long R3 IGF-I, is an 83-amino-acid analogue with a 13-residue N-terminal extension and an arginine substitution at position 3 of the IGF-I sequence. Published work has examined its reduced interaction with IGF binding proteins and its model-dependent biological effects. The cited pig study and general binding-protein review do not establish a circulating half-life for this product.
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Long R3 IGF-I study in pigs; effects in this animal model do not establish this product’s pharmacokinetics.
General review of IGF binding-protein signaling; not a direct study of IGF-1 LR3 or this product.
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