Reduced IGFBP binding
E3R + 13-aa extension lower IGFBP-3 affinity ~100x.
FOR RESEARCH PURPOSES ONLY — This compound is not FDA approved. All data presented is from peer-reviewed literature for educational reference.
Growth Factor
IGF-1 LR3
- Long R3 IGF-1
- LR3 IGF-1
- rh-IGF-1 LR3
CAS: 143045-27-6
A long-acting analogue of insulin-like growth factor 1 engineered with reduced binding-protein affinity, used in research models of cell proliferation, protein synthesis, and IGF-1 receptor signaling.
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Extended half-life
~20–30 h in research models vs minutes for native IGF-1.
99%+ identity purity
HPLC + MS verified per batch. CoA included.
What Is IGF-1 LR3?
IGF-1 LR3 is an 83-amino-acid analogue of human IGF-1 with two engineered changes: a 13-amino-acid N-terminal extension and substitution of glutamic acid at position 3 with arginine (the "R3" of the name). These modifications reduce binding to insulin-like growth factor binding proteins (especially IGFBP-3) roughly 100-fold versus native IGF-1, which extends circulating half-life in research models from minutes to approximately 20–30 hours. Signaling at the IGF-1 receptor (PI3K/Akt and MAPK pathways) is preserved.
Technical specifications
Type
Recombinant 83-amino-acid IGF-1 analogue
Formula
C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉
Molecular weight
9111.45 g/mol
CAS number
143045-27-6
Appearance
White lyophilized powder
Identity purity
≥ 99% (HPLC + MS)
Peer-reviewed research
- J Anim SciLong [R3] insulin-like growth factor-I reduces growth, plasma growth hormone, IGF binding protein-3 and endogenous IGF-I concentrations in pigs
- Endocr RevSignaling Pathways of the Insulin-like Growth Factor Binding Proteins
Frequently researched together
IMPORTANT RESEARCH NOTICE
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.