Reduced IGFBP binding
N-terminal truncation drops IGFBP affinity vs native IGF-1.
FOR RESEARCH PURPOSES ONLY — This compound is not FDA approved. All data presented is from peer-reviewed literature for educational reference.
Growth Factor
IGF-1 DES
- DES(1-3) IGF-1
- des-IGF-1
- des-1,3-IGF-I
CAS: 112603-35-7
A truncated analogue of insulin-like growth factor 1 missing the first three N-terminal residues, studied for IGF-1 receptor activation with reduced binding-protein sequestration, including neurotrophic activity in CNS models.
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CNS-relevant signaling
Characterized at hippocampal excitatory synapses via PI3K.
99%+ identity purity
HPLC + MS verified per batch. CoA included.
What Is IGF-1 DES?
IGF-1 DES is a 67-amino-acid truncated variant of native human IGF-1 in which the first three N-terminal residues (Gly-Pro-Glu) are absent. The truncation markedly reduces affinity for the IGF binding proteins (IGFBP-1 through 6), allowing the molecule to act on the IGF-1 receptor with less binding-protein sequestration than native IGF-1. Preclinical work has examined effects on AMPA-receptor-mediated synaptic potentiation in the CA1 region of rat hippocampus and PI3K/Akt-dependent neurotrophic signaling, distinct from LR3-style systemic anabolic studies.
Technical specifications
Type
Recombinant 67-amino-acid IGF-1 analogue
Formula
C₃₂₁H₄₉₅N₈₃O₉₅S₇
Molecular weight
7372.79 g/mol
CAS number
112603-35-7
Appearance
White lyophilized powder
Identity purity
≥ 99% (HPLC + MS)
Peer-reviewed research
- J NeurophysiolFunctional characterization of des-IGF-1 action at excitatory synapses in the CA1 region of rat hippocampus
- Neurosci LettInsulin-like growth factor-I enhances the biological activity of brain-derived neurotrophic factor on cerebrocortical neurons
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IMPORTANT RESEARCH NOTICE
Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.
By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.